Musculoskeletal ultrasound examination of the ankle has never been performed during an episode of ELE. We hypothesize that ELE is associated with underlying musculoskeletal pathology. In order to support this hypothesis, ankle musculoskeletal ultrasound will be performed within 24 hours of onset of ELE in 15 patients diagnosed with FMF. Results will be correlated with clinical parameters, serum inflammatory markers, and ankle radiography.
It typically presents with painful, well-demarcated, and unilateral erythema overlying the ankle, and resolves spontaneously within 24 to 72 hours.
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It is most often monoarticular and involves the ankles in almost half of cases. However, the overlap between the clinical presentation of ELE and ankle arthritis in FMF poses a diagnostic challenge.
Published by Andrei Ioan Bogdan at 20 apr. Fiecare dintre aceste conditii vor fi descrise si explicate. Aceste probleme afecteaza sportivii de cele mai multe ori, in special alergatorii, jucatorii de baschet, dar si orice persoana implicata in sporturi cu sarituri. Aceste afectiuni sunt, de asemenea, frecvente in randul persoanelor de varsta mijlocie, adulti, atat activi cat si sedentari.
Musculoskeletal ultrasound is a simple and sensitive technique for the evaluation of articular and peri-articular structures. Only one study described sonographic articular involvement in FMF. In 29 asymptomatic patients, an increased prevalence of knee effusion, retrocalcaneal bursitis and medial tenosynovitis of the ankle was noted masaj pentru artroza genunchiului with the control group.
Irrespective of joint involvement, an increased prevalence of enthesopathy has also been documented by ultrasound in patients with FMF, thus strengthening its association with spondyloarthropathy. However, no study has evaluated by ultrasound the articular and peri-articular involvement of the ankle during an episode of ELE. To date, the treatment of ELE involves ankle offloading and administration of analgesics. By calcaneal bursa a better understanding of its pathogenesis, sonographic confirmation of articular and peri-articular involvement of the ankle during an episode of ELE will potentially allow to optimize its therapeutic management.
Eligible patients will be contacted by mail or email to inform them of the study. Those interested in participating will be advised to contact the investigators by email or phone at the onset of ELE. Patients presenting with ELE during their visit in the internal medicine department of Tenon Hospital will also be screened for eligibility.
A visit between the participant and attending physician will be scheduled within 24 hours of the onset of ELE. The usual management of ELE will not be altered. It will involve a blood test for complete blood count and C-reactive protein measurement to confirm the inflammatory syndrome, as well as an x-ray of the ankles to exclude an underlying structural pathology.
Analgesics will be prescribed for symptomatic relief.
The inclusion visit for the study will be integrated to this medical consultation. In search of potential confounding factors for sonographic musculoskeletal abnormalities, the following data will also be collected: professional occupation, physical activity type and frequencypresence of pes planus or cavus, pre-existing ankle pain, and chronic ankle edema.
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Sonographic evaluation of the articular calcaneal bursa periarticular structures of the two ankles will calcaneal bursa performed using the Samsung UGEO H60 echograph, in operation since In order to ensure reproducibility, the evaluation will be completed by a single examiner throughout the study.
Following the inclusion visit, a follow-up by email or phone will be done within one week of inclusion in order to confirm calcaneal bursa exact duration of ELE. This information will allow us to confirm the diagnosis of ELE, which normally resolves spontaneously within 72 hours, in contrast to its main differential diagnosis, namely erysipelas. Thereafter, there will be no additional follow-up as part of this study. The patient inclusion phase will last 8 months, followed by 3 months of acțiune glucozamină și condroitină analysis.
We estimate that 8 months will be sufficient to recruit 15 patients among our study population.
The number 15 was arbitrarily chosen because FMF is a rare disease, and the incidence of ELE in this population is highly variable and therefore poorly defined in the literature. Regarding data analysis, clinical, biological, radiographic and sonographic data will be presented as medians ± interquartile interval when these are continuous variables, and as absolute numbers with proportion when these are categorical variables. Sonographic and radiographic findings will calcaneal bursa compared between the ankles ipsilateral and contralateral to ELE.
Continuous variables will be compared with the Mann-Whitney test.
Categorical variables will be compared with the Fisher test. In order to determine whether clinical and paraclinical parameters are correlated with the presence of sonographic musculoskeletal pathologies, univariate and multivariate analyses will be performed using a logistic regression model.
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